While raising three children and taking care of the household, Fanny Angelina Hesse supported, documented, and archived her husband’s work, creating stunning scientific illustrations of bacterial and fungal colonies. During the hot Summer of 1881, she watched as Hesse struggled with gelatine-based growth media. Fanny Angelina, recalling the stability of her agar-based desserts, suggested that they try that instead. Hesse wrote a letter to Koch informing him about the switch, and Koch mentioned agar for the first time in his 1882 groundbreaking paper on the discovery of the tuberculosis bacillus.
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An example of dithering using random noise. Top to bottom: original gradient, quantised after dithering, quantised without dithering.